PEDIATRICS Vol. 36 No. 2 August 1965, pp. 292-293
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Letters to the Editor

RICHARD N. FINE M.D., MAY Y. F. WOO WANG M.D., and CLARK W. HEATH JR. M.D.

We wish to thank Drs. Hecht and Scott for their comments. We agree with their statistical analysis of our data, and do not argue with the fact that nuclear projections in neutrophils are statistically more frequent in peripheral blood smears from patients with D1 trisomy than in control smears. The point of our paper, however, was not to dispute this statistical fact. We wished instead to demonstrate that the mere presence of nuclear projections per se is not of practical help in diagnosing D1 trisomy since such projections are present in normal smears, both male and female. This, of course, is particularly true for female patients where, as Drs. Hecht and Scott point out, "drumstick and sessile" projections further complicate the picture.