PEDIATRICS Vol. 36 No. 2 August 1965, pp. 183-191
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RELATIVE HYPERMETABOLISM IN INFANTS WITH CONGENITAL HEART DISEASE AND UNDERNUTRITION

Martin H. Lees M.D.1, J. David Bristow M.D.1, Herbert E. Griswold M.D.1, and Richard W. Olmsted M.D.1

1 Department of Pediatrics and Division of Cardiology, University of Oregon Medical School, Portland, Oregon

1. Twenty-one infants with various forms of congenital heart disease leading to congestive heart failure, arterial unsaturation, or a combination of both events were studied with respect to resting oxygen consumption. Comparison was made with 21 control infants considered to be of normal growth and to have normal cardiac and respiratory systems.

2. Mean oxygen consumption for infants with heart disease was 9.3±2.4 ml/min/ kg compared to 7.3±0.8 ml/mm/kg for controls. Markedly undergrown infants with heart disease (60% or less of the 50th percentile weight for age) had a mean oxygen consumption of 10.9±1.4 ml/mm/kg compared to a mean of 7.5±2.0 ml/min/kg for infants with heart disease who were greater than 60% of the 50th percentile weight for age. Relative hypermetabolism seemed to relate to the degree of undernutrition rather than to any specific clinical finding.

3. Possible mechanisms of undernutrition and of relative hypermetabolism in the infant with heart disease are discussed.

Submitted on November 10, 1964
Accepted on January 21, 1965




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