PEDIATRICS Vol. 35 No. 6 June 1965, pp. 1003-1005
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Depigmented Nevi: The Earliest Sign of Tuberous Sclerosis

ARNOLD P. GOLD M.D.1 and JOHN M. FREEMAN M.D.2

1 The Department of Neurology, (Division of Child Neurology), Columbia Presbyterian Medical Center, Neurological Institute, 710 West 168th Street New York, N.Y. 10032
2 The Department of Pediatrics, Columbia Presbyterian Medical Center, Neurological Institute, 710 West 168th Street New York, N.Y. 10032

Depigmented nevi may be the initial cutaneous manifestation of tuberous sclerosis. In the child presenting with infantile spasms, the presence of depigmented nevi suggest the diagnosis of tuberous sclerosis.