PEDIATRICS Vol. 35 No. 5 May 1965, pp. 765-769
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ESTIMATION OF THE SERUM BETA1C GLOBULIN CONCENTRATION: ITS RELATION TO THE SERUM HEMOLYTIC COMPLEMENT TITER

Martin R. Klemperer M.D.1, Samuel P. Gotoff M.D.1, Chester A. Alper M.D.1, Alan S. Levin M.D.1, and Fred S. Rosen M.D.1

1 Department of Pediatrics and Medicine, Harvard Medical School, and the Children's Hospital Medical Center

The depression of a single serum protein, the beta1C globulin (normally 130-155 mg/ 100 ml) to below 80 mg/100 ml is manifested by a decreased hemolytic complement titer. Since this protein can be measured by an immunodiffusion methol, its immunoassay can be used as a substitute for the hemolytic titration of complement in the diagnosis of patients with acute glomerulonephritis, systemic lupus erythematosus, and the nephrotic syndrome. A rapid immunoassay of the serum beta1C globulin can be easily performed.

Submitted on July 6, 1964
Accepted on January 6, 1965