PEDIATRICS Vol. 35 No. 5 May 1965, pp. 759-764
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MATERNAL, CORD, AND SERIAL VENOUS BLOOD: PROTEIN-BOUND IODINE, THYROID-BINDING GLOBULIN, THYROID-BINDING ALBUMIN, AND PREALBUMIN VALUES IN PREMATURE INFANTS

Ralph E. Perry M.D.1, Joan E. Hodgman M.D.1, and Paul Starr M.D.1

1 Departments of Pediatrics and Medicine, University of Southern California School of Medicine and the Premature Center of the Los Angeles County Hospital

1. P.B.I. and thyroid-binding protein levels in mothers delivering premature infants of varying weights are the same as those reported for mothers delivering at term. The maternal T.B.G. is from 50-60% greater than the T.B.G. of the cord blood.

2. The cord P.B.I. in the smallest infants is significantly lower than their mothers' and is lower than that of the babies weighing over 1,500 gm.

3. The characteristic newborn P.B.I. pattern of abrupt rise in the 48 hours after birth followed by a more gradual fall has been established for the premature infant. The magnitude of rise is less in the smallest prematures. The increase in P.B.I. following delivery is found in all weight groups and does not appear to be associated with the gestational age.

4. T.B.G. levels in prematures are the same as those reported in term infants, and are stable throughout the first 10 days. The rise in P.B.I. cannot be attributed to a change in T.B.G.

5. A pattern of alterations in T.B.A. and T.B.P.A. has been described.

Submitted on July 1, 1964
Accepted on October 8, 1964