PEDIATRICS Vol. 35 No. 3 March 1965, pp. 506
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Letters to the Editor

JOHN A. MANGOS M.D.

In regard to the "Letter to the Editor" by Dr. George Cassady, we feel that he has misinterpreted the opening paragraph of our article "Familial Juvenile Nephronophthisis" (Pediatrics, 34:337, 1964). We did not suggest that the excellent work of Shafer, Scriver, and Efron supported a cause and effect relationship between the described biochemical defect and the syndrome of hereditary nephritis and deafness. Our statement "recognition and study of this disease has led to the demonstration of a biochemical defect" simply intends to emphasize the importance of recognition of specific clinical syndromes which lead to the study of more cases and frequently to the discovery of important biochemical or other abnormalities in affected individuals.