PEDIATRICS Vol. 35 No. 3 March 1965, pp. 373-381
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Orzalesi, M. M.
Right arrow Articles by Cook, C. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Orzalesi, M. M.
Right arrow Articles by Cook, C. D.

THE DEVELOPMENT OF THE LUNGS OF LAMBS

M. M. Orzalesi M.D.1, E. K. Motoyama M.D.2, H. N. Jacobson M.D.3, Y. Kikkawa M.D.4, E. O. R. Reynolds M.B.5, and C. D. Cook M.D.6

1 The Children's Hospital Medical Center, the Boston Lying-in Hospital
2 The Department of Pediatrics, Harvard Medical School, Boston
3 The Department of Obstetrics, Harvard Medical School, Boston
4 The Departments of Gynecology, Harvard Medical School, Boston
5 The Department of Pathology, Albert Einstein College of Medicine, New York City
6 The Department of Pediatrics, Yale University School of Medicine, New Haven

1. Lambs with estimated gestational ages from 55 to 154 days were delivered by cesarean section. Observations were made on animals in the fetal state and after the onset of respiration in lambs of more than 130 days gestation. Spontaneously born lambs were also studied.

2. Measurements of arterial blood gas tensions, pH, lactic acid concentration, and blood pressure showed that the animals were always in good condition.

3. Normal surface activity of lung extracts was first found in fetuses of about 126 days gestation and was present in the lambs of more than 130 days gestation which breathed.

4. Electron microscopy showed that cells containing osmiophilic inclusion bodies first appeared at about 120 days gestation and preceded by only a few days the appearance of normal surface activity of lung extracts. The number of cells containing osmiophilic inclusion bodies as well as the total number of inclusion bodies increased toward term. There was no apparent difference in the number of these cells or the total number of inclusion bodies in the lungs of lambs which breathed as compared to fetuses of comparable gestational age.

5. The water content of the lungs per unit of dry tissue decreased during gestation until about 95 days and then increased again until term. After the onset of respiration the water content rapidly decreased.

6. The blood content of the lungs per unit of dry tissue increased significantly during gestation and there was a further probable increase after the onset of respiration.

Submitted on August 6, 1964
Accepted on October 16, 1964




This article has been cited by other articles:


Home page
 ScienceHome page
A. H. Niden
Bronchiolar and Large Alveolar Cell in Pulmonary Phospholipid Metabolism
Science, December 8, 1967; 158(3806): 1323 - 1324.
[Abstract] [PDF]