PEDIATRICS Vol. 35 No. 1 January 1965, pp. 65-69
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ON THE TRANSPORT OF INSULIN ACROSS THE HUMAN PLACENTA

David Gitlin M.D.1, Jesús Kumate M.D.2, and Carlos Morales M.D.3

1 Hospital de Gineco-Obstetricia, Centro Médico del I.M.S.S.
2 The Hospital Infantil, Mexico, D.F.
3 The Children's Hospital, Pittsburgh, Pennsylvania

The maternofetal transfer of I131-labeled human insulin was studied in 9 women undergoing caesarean section. The data suggest that insulin readily traverses the human placenta and that the amount transferred from mother to fetus is equivalent to 33% of the insulin utilized by the normal fetus at term and this amount is also equal to 33% of the insulin synthesized by the normal fetus at term. The placenta appears to be equally permeable in the direction of fetus to mother.

Submitted on June 1, 1964
Accepted on July 28, 1964