PEDIATRICS Vol. 35 No. 1 January 1965, pp. 36-41
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FATAL MYOCARDITIS IN AN ADOLESCENT CAUSED BY COXSACKIE VIRUS, GROUP B, TYPE FOUR

Shyamal K. Sanyal M.B.B.S.1, Mehdy Mahdavy M.D.1, Mary O. Gabrielson M.D.1, Romeo A. Vidone M.D.1, and Marie J. Browne M.D.1

1 Departments of Pediatrics and Pathology, and Department of Public Health and Epidemiology of the Yale University School of Medicine and the Grace-New Haven Community Hospital, New Haven, Connecticut

A fatal case of myocarditis apparently due to Coxsackie virus, group B, type 4, occurring in a 13-year-old girl has been presented. This is the first reported fatal case beyond 2 years of age. Isolation of the virus from the pericardial fluid and the presence of a high homologous serum neutralizing antibody titer strongly suggested the diagnosis. Although generally considered to be a benign entity in older children and adults, myocarditis due to Coxsackie virus may be fatal.

Submitted on June 19, 1964
Accepted on July 27, 1964