PEDIATRICS Vol. 34 No. 5 November 1964, pp. 615-620
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DISACCHARIDASES OF INTESTINAL MUCOSA IN A PATIENT WITH SUCROSE INTOLERANCE

Kari Launiala M.D.1, Jaakko Perheentupa M.D.1, Jarmo Visakorpi M.D.1, and Niilo Hallman M.D.1

1 The Children's Hospital, University of Helsinki, Finland

A thorough clinical and enzymological study is reported in a patient suffering from typical sucrose intolerance. In addition to sucrose intolerance, a subclinical intolerance of maltose was demonstrated.

Enzyme assay in a specimen of duodenal mucosa obtained by peroral tube biopsy revealed decreased activities of isomaltase, sucrase, and maltase. The assay was repeated following a three-month period on a sucrose-free diet with identical results.

In the light of these findings the present information on intestinal agr-glucosidases is discussed. The authors suggest that sucrose intolerance is due to a defect of one mucosal enzyme, the various agr-glucosidase activities of which are differently affected by heat.

Submitted on March 16, 1964
Accepted on June 10, 1964