PEDIATRICS Vol. 34 No. 5 November 1964, pp. 609-614
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STUDIES OF SMALL INTESTINE DURING DEVELOPMENT

IV. Digestion of Lactose as Related to Lactosuria in the Rabbit

Velimir V. Sterk M.D.1 and Norman Kretchmer M.D., Ph.D.1

1 Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California

The data indicate that hydrolysis of lactose is maximal perinatally. The increase in activity of this enzyme is dissociated from intestinal growth by the time the rabbit is 21 days old. There is passive diffusion of the lactose across an intestinal sac which is related only to concentration and not the age of the animal. When lactose is administered to rabbits of different ages, lactosuria is observed mainly in older animals.

Submitted on January 9, 1964
Accepted on July 15, 1964