PEDIATRICS Vol. 34 No. 3 September 1964, pp. 407-411
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EFFECTS OF OSMOTIC GRADIENTS ACROSS THE PRIMATE PLACENTAL UPON FETAL AND PLACENTAL WATER CONTENTS

Paul D. Bruns 1, Andre E. Hellegers 1, A. Elmore Seeds Jr. 1, Richard E. Behrman 1, and Frederick C. Battaglia 1

1 Laboratory of Perinatal Physiology, National Institute of Neurological Diseases and Blindness, N.I.H., P.H.S., USDHEW, San Juan, Puerto Rico

Infusions of 2.7 g/100 ml sodium chloride or 30 g/100 ml disaccharide solutions into the maternal circulation of pregnant rhesus monkeys produced a significant reduction in fetal and placental total water content. At the same time large transplacental total solute concentration gradients were produced.

The injection of sucrose into the amniotic fluid of pregnant rhesus monkeys produced a reduction in fetal total body water alone. The significance of these differences is discussed.

Submitted on February 6, 1964
Accepted on March 30, 1964