PEDIATRICS Vol. 34 No. 3 September 1964, pp. 401-406
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ANTICOAGULASE IN SERA OF CHILDREN WITH STAPHYLOCOCCAL INFECTIONS

Ramon Velarde-Frias M.S., M.D.1 and Morris F. Shaffer D.Phil.1

1 Department of Microbiology, Tulane University, School of Medicine, New Orleans, Louisiana

A small series of children undergoing intensive chemotherapy for staphylococcal disease were followed with respect to serum anticoagulase levels. The majority showed no appreciable neutralizing antibody versus any of a battery of 15 coagulases prepared from "standard" strains of staphylococci representing several phage groups. Three individuals exhibited relatively high (and in one instance a significantly rising) titer versus coagulase derived from the etiologic organism or from strains of closely related phage types. These antibodies were possibly the result of a prolonged initial episode of exposure to a single strain of staphylococci.

Submitted on April 3, 1964
Accepted on April 28, 1964