1 Department of Research, British American Hospital, Lima, Peru, and Pan American Health Organization
In four severely malnourished infants who were rehabilitated on high-calorie, low-Cu diets, we have observed the appearance of severe anemia, marked neutropenia, scurvy-like bone changes, and hypocupremia. In 2 cases there was a prompt and dramatic response to Cu supplementation. In the other 2, slower but good responses were obtained with vitamin B12; supplemental Cu produced further responses. The Cu requirement of rapidly growing infants with poor stores is estimated at between 42 and 135 µg/kg/day.
Submitted on December 23, 1963
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