Advertising Disclaimer
PEDIATRICS Vol. 34 No. 1 July 1964, pp. 4-13
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Warren, R. J.
Right arrow Articles by Robbins, F. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Warren, R. J.
Right arrow Articles by Robbins, F. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

THE RELATIONSHIP OF MATERNAL ANTIBODY, BREAST FEEDING, AND AGE TO THE SUSCEPTIBILITY OF NEWBORN INFANTS TO INFECTION WITH ATTENUATED POLIOVIRUSES

Robert J. Warren M.D.1, Martha L. Lepow M.D.1, Glenn E. Bartsch D.Sc.1, , Frederick C. Robbins M.D.1

1 Departments of Pediatrics and Preventive Medicine, Western Reserve University School of Medicine and Cleveland Metropolitan General Hospital

1. Over 1,000 infants were fed attenuated polioviruses during the first 3 months of life and susceptibility to infection with these agents was shown to be related to dose of virus, titer of maternal antibody, method of milk feeding, and age at vaccination.

2. Larger doses of virus elicited a response in a high proportion of infants, but even the smallest dose employed was of nearly optimal effectiveness in infants with little or no maternal antibody.

3. No significant differences between the 3 types of polioviruses were observed other than those which could be related to differences in maternal antibody titer for the 3 types.

4. Maternal antibody had a direct relationship to the incidence of infection, particularly in breast-fed babies and in bottle-fed infants vaccinated on the first day of life.

5. Human milk contains poliovirus neutralizing substances (probably antibody but not specifically characterized) in concentrations related to the antibody titer in the mother's serum. However, a number of significant discrepancies between the antibody content of the serum and milk or colostrum were observed. It is postulated that infection is prevented by neutralization of the virus in the lumen of the infant's gut.

6. Susceptibility of bottle-fed babies increases rapidly during the first three days of life, but remains relatively unchanged thereafter. A reasonable hypothesis to explain this phenomenon is that maternal antibody in the infant's gut, whether from ingested amniotic fluid or by leakage from his circulation into the intestine, inactivates virus given on the first few days of life, but not later.

Submitted on November 18, 1963
Accepted on February 8, 1964


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 CLIN PEDIATRHome page
F. O. Adebonojo
Artificial vs Breast Feeding: Relation to Infant Health in a Middle Class American Community
Clinical Pediatrics, January 1, 1972; 11(1): 25 - 29.
[Abstract] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
S. A. PLOTKIN, M. KATZ, R. E. BROWN, and J. S. PAGANO
Oral Poliovirus Vaccination in Newborn African Infants: The Inhibitory Effect of Breast Feeding
Arch Pediatr Adolesc Med, January 1, 1966; 111(1): 27 - 30.
[Abstract] [PDF]