PEDIATRICS Vol. 33 No. 6 June 1964, pp. 999
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Pediatric Hazards of Drugs in Solutions Convenient for Administration to Adults

STANTON G. AXLINE M.D.1 and HAROLD J. SIMON M.D.1

1 Department of Medicine, Stanford University School of Medicine, Palo Alto, California

Studies on the clinical pharmacology of drugs in newborn infants have uncovered a problem of overdosage which may be more common than generally appreciated. Several medicaments are available only in a limited number of highly concentrated formulations. The requirements of premature and full-term newborn infants for very small total dosages necessitate very careful measurements of minute quantities of drug, and overdosage can readily occur.

Specifically, Kanamycin is available in only two formulations for injection containing respectively 250 and 333 mg/ml. The dosage of this agent for newborn infants is approximately 8 mg/Kg of body weight 12 hourly.