PEDIATRICS Vol. 33 No. 4 April 1964, pp. 534-540
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ECHO II OUTBREAK IN NEWBORN INFANTS AND MOTHERS

Sumner Berkovich M.D.1 and Sidney Kibrick M.D., Ph.D.1

1 The Research Division of Infectious Diseases, the Children's Hospital Medical Center, Boston; the Department of Pediatrics, State University of New York, Downstate Medical Center, Brooklyn; the Evans Memorial Department of Clinical Research, Massachusetts Memorial Hospitals and the Departments of Medicine and Microbiology, Boston University School of Medicine, Boston University Medical Center

A late summer outbreak of illness involving newborn infants and mothers is described. Seven infants and five mothers were studied. Although three enterovirus types were recovered from the infants, the outbreak was associated with infection by a variant of ECHO 11. Clinical signs included fever, diarrhea, upper respiratory disease, and aseptic meningitis. In three infants the antibody response significantly exceeded that of the mother. The evidence for an etiologic association of ECHO 11 infection with disease is reviewed.

Submitted on August 16, 1963
Accepted on October 20, 1963