PEDIATRICS Vol. 33 No. 4 April 1964, pp. 507-511
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STUDIES ON FOLIC ACID IN INFANCY

I. Blood Levels of Folic and Folinic Acid in Healthy Infants

Yehuda Matoth M.D.1, Ariela Pinkas M.Sc.1, Rina Zamir M.Sc.1, Fouad Mooallem M.D.1, and Nathan Grossowicz Ph.D.1

1 Department of Pediatrics, Sharon Hospital, and the Laboratory for Pediatric Research of the Rogoff Medical Research Institute, Beilinson Medical Center, Petah Tikva, and the Department of Bacteriology, Hebrew University—Hadassah Medical School, Jerusalem, Israel

The level of folic and folinic acid in whole blood was assayed in 373 healthy infants from birth to one year. Folic acid was high at birth and dropped gradually over the first 8 postnatal weeks. The mean value for the remainder of the first year was significantly below the adult mean. Folinic acid was likewise high at birth and dropped parallel with the folic acid. However, following the initial drop, folinic acid mean values remained well above the adult mean. Folic and folinic acid values were higher in breast-fed than in artificially fed infants and lower in infants whose economic status was poor than in babies belonging to families of higher income.

Submitted on April 24, 1963
Accepted on September 26, 1963




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N Colman, N Hettiarachchy, and V Herbert
Detection of a milk factor that facilitates folate uptake by intestinal cells
Science, March 27, 1981; 211(4489): 1427 - 1429.
[Abstract] [PDF]