PEDIATRICS Vol. 33 No. 3 March 1964, pp. 380-387
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ACUTE TUBULAR NEPHROSIS IN THE NEWBORN INFANT, A MANIFESTATION OF ANOXIA

John Kwittken M.D.1 and Leopold Reiner M.D.1

1 The Department of Laboratories, The Bronx-Lebanon Hospital Center, Fulton Division

The presence of cellular renal casts in the newborn infant is considered evidence of renal tubular injury. A cause-and-effect relationship between anoxia and these renal lesions is suggested by this study. The histopathologic manifestations of tubular disease best demonstrated in sections stained for fat and with the periodic acid-Schiff routine are dependent not only upon the severity and duration of anoxia, but also upon the length of survival after injury. In this regard, the finding of urinary cellular casts in the newborn infant may suggest to the clinician an early and vigorous approach against the pathologic effects of anoxia.

Submitted on April 26, 1963
Accepted on November 4, 1963