PEDIATRICS Vol. 33 No. 2 February 1964, pp. 251-257
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GOUT IN INFANCY MANIFESTED BY RENAL FAILURE

Ira M. Rosenthal M.D.1, Saeed Gaballah Ph.D.2, and Max E. Rafelson Jr. Ph.D.3

1 Department of Pediatrics, University of Illinois College of Medicine, Research and Educational Hospitals
2 Department of Biological Chemistry, University of Illinois College of Medicine, Research and Educational Hospitals
3 Department of Biochemistry, Presbyterian-St. Luke's Hospital, Chicago

A case of gout in a male infant manifest at the age of 7 weeks by signs of renal failure is reported. The child recovered after alkalinization of his urine increased the solubility of precipitated uric acid in the renal tubules. Evidence for gout was found in the maternal and paternal sides of the family. A metabolic study employing N15-labeled glycine demonstrated increased incorporation of glycine into uric acid of the same magnitude previously found in some adult patients with gout.

Submitted on May 9, 1963
Accepted on July 12, 1963