PEDIATRICS Vol. 33 No. 2 February 1964, pp. 239-244
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TREATMENT OF A CASE OF NONTUMOROUS CUSHING'S SYNDROME WITH o,p'DDD

J. Bar-Hay M.D.1, A. Benderly M.D.1, and G. Rumney Ph.D.1

1 Department of Pediatrics A, Rambam Government Hospital, Haifa, and Endocrine Laboratory, Beilinson Hospital, Petach-Tikva, Israel

A case of a nontumorous Cushing's syndrome in a 10-year-old girl is presented. The diagnosis was based on the clinical picture, the high levels of urinary steroids and plasma 17-OH corticosteroids, the results of ACTH stimulation tests, and finally by the histology of the left adrenal.

Therapy with o,p'DDD had a dramatic effect on the patient's condition. The typical signs of Cushing's syndrome disappeared, and the girl is developing normally. The urinary steroids and the plasma 17-OH corticosteroids returned to normal levels. The ACTH stimulation tests gave results indicative of a normally functioning adrenal gland.

Submitted on May 3, 1963
Accepted on June 14, 1963