PEDIATRICS Vol. 33 No. 2 February 1964, pp. 194-204
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Payne, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Payne, R.

NEONATAL NEUTROPENIA AND LEUKOAGGLUTININS

Rose Payne Ph.D.1

1 Department of Medicine, Stanford University School of Medicine, Palo Alto, California

Support for the existence of an immunoneutropenia of the neonatal period was not obtained. The leukocyte counts of 39 full-weight newborn infants who stimulated their mothers to form leukoagglutinins were compared with the counts of 76 newborns who failed to stimulate formation of these agglutinins. A significant difference between the mean total leukocyte or differential counts for the two groups was not observed. The leukocyte counts of both groups throughout the first four days of life were in close agreement with the accepted values for this period. The platelet counts for 10 full-weight newborn infants who stimulated white cell agglutinin formation did not differ over the first four days of life from a control group of 37 newborns. Transplacental passage of the leukocyte agglutinins was demonstrated in 15 of 49 newborns examined. Persistence of antibody in the serum of the newborn was variable It was concluded that in this series transplacental passage of leukocyte agglutinins from sensitized mothers to newborns with antigen did not induce significant leukopenia or neutropenia.

Submitted on June 6, 1963
Accepted on October 15, 1963