PEDIATRICS Vol. 33 No. 2 February 1964, pp. 184-192
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gitlin, D.
Right arrow Articles by Craig, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gitlin, D.
Right arrow Articles by Craig, J. M.

THYMIC ALYMPHOPLASIA AND CONGENITAL ALEUKOCYTOSIS

David Gitlin M.D.1, Gordon Vawter M.D.1, and John M. Craig M.D.1

1 Departments of Pediatrics and Pathology, Harvard Medical School, Children's Hospital Medical Center, and the Boston Lying-In Hospital, Boston, Massachusetts

Thymic alymphoplasia has been found to be a part of the histopathological picture of congenital aleukocytosis. As in children with congenital agammaglobulinemia who have thymic alymphoplasia, the thymic anomaly is accompanied by lymphopenia and a marked generalized paucity of lymphocytes in the tissues or lymphocytic hypoplasia. The patient described in this report, a girl who succumbed at 15 days to overwhelming bacterial infection, also had agranulocytosis and no granulocytes or granulocyte precursors could be discerned in her bone marrow; megakaryocytes were present in the marrow in normal numbers and hematocytoblasts, normoblasts, and monocytes were present as well. Hence, the defect in this syndrome, whether intracellular or conveyed humorally, would appear to be highly selective. On the basis of the normal development of the human thymus and other lymphoid tissues including the bone marrow, it would seem that the defect in the development of the lymphocyte was manifest at or before the 10th week of gestation. The possible relations between lymphocytes, plasma cells, and granulocytes are discussed.

Submitted on May 20, 1963
Accepted on August 26, 1963




This article has been cited by other articles:


Home page
 BloodHome page
J.-F. Emile, F. Geissmann, O. d. l. C. Martin, I. Radford-Weiss, Y. Lepelletier, B. Heymer, T. Espanol, K. B. de Santes, Y. Bertrand, N. Brousse, et al.
Langerhans cell deficiency in reticular dysgenesis
Blood, July 1, 2000; 96(1): 58 - 62.
[Abstract] [Full Text] [PDF]