PEDIATRICS Vol. 32 No. 6 December 1963, pp. 1039-1043
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ATTENUATED POLIOVIRUS INFECTION IN INFANTS FED COLOSTRUM FROM POLIOMYELITIS IMMUNE COWS

Antonio J. Gonzaga M.D.1, Robert J. Warren M.D.2, and Frederick C. Robbins M.D.3

1 The Department of Medicine, Cleveland Metropolitan General Hospital, Cleveland, Ohio
2 The Department of Pediatrics, Cleveland Metropolitan General Hospital, Cleveland, Ohio
3 Western Reserve University School of Medicine, Cleveland, Ohio

The ingestion of bovine colostrum, containing poliovirus neutralizing antibody, before the administration of 105.5 TCID50 of Sabin Type 2 vaccine prevented viral infection of the gastrointestinal tract in 8 of 11 3-day-old infants during a 16-day period of observation. The ingestion of colostrum after as short an interval as 2 hours following administration of the vaccine did not affect the incidence of infection, but it did appear either to delay the establishment of infection or to interfere temporarily with the isolation of virus from the feces. The ingestion of colostrum that did not possess poliovirus neutralizing antibody did not influence the incidence of infection.

Submitted on May 20, 1963
Accepted on June 13, 1963