PEDIATRICS Vol. 32 No. 6 December 1963, pp. 1033-1038
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THE PRESENCE OF LACTULOSE IN THE URINE OF INFANTS WITH LACTOSURIA

Theo Gerritsen D.Sc.1, Luc Lemli M.D.1, Louis J. Ptacek M.D.1, and Harry A. Waisman Ph.D., M.D.1

1 Department of Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin

Two patients with failure to thrive are described who excreted lactose in the urine together with the non-naturally occurring disaccharide lactulose. It was demonstrated that both sugars originated from the diet, a canned liquid modified milk product. It is suggested that the beta-galactosidase activity in the gut was decreased, although blood glucose levels during a lactose tolerance test were near normal. The patients outgrew this partial enzyme defect before the age of one year.

Submitted on February 13, 1963
Accepted on June 1, 1963