PEDIATRICS Vol. 32 No. 6 December 1963, pp. 1002-1006
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VARIATIONS IN GLUCAGON RESPONSE AMONG JUVENILE DIABETICS

Donnell D. Etzwiler M.D.1

1 St. Louis Park Medical Center, and Department of Pediatrics, University of Minnesota School of Medicine

Glucagon or a placebo preparation was administered to 65 juvenile diabetics on 74 separate occasions. When the initial blood glucose of these children showed them to be in reasonably good control, glucagon produced a hyperglycemic effect. However, when the blood glucose levels were markedly elevated, the effect of glucagon was less predictable. The depletion of liver glycogen stores and the possible effect of contaminating insulin in glucagon preparations are discussed.

Submitted on March 25, 1963
Accepted on May 20, 1963