1 Roswell Park Memorial Institute, State University of New York, Buffalo, New York
As all relatively new fields of investigation, the study of the fibrinolysin system is going through the growing pains of the development and interpretation of methodology. It is quite true that most of the fibrinolytic assays have been done by using as substrate bovine fibrinogen (Astrup, T., Müllertz, S., Arch. Biochem. 40:346, 1952), various synthetic esters (Troll, W., Sherry, S., Wachman, J., J. Biol. Chem. 208:85, 1954) or casein (Müllertz, S., Biochem. J. 61:424, 1955).