PEDIATRICS Vol. 32 No. 5 November 1963, pp. 919-922
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Serum Levels of Potassium Penicillin V following Oral Administration to Febrile and Afebrile Children

F. WHITEHOUSE JR. M.D.1, S. A. OBENG M.D.2, A. R. PEQUET M.D.2, J. K. CHAMNESS M.D.2, J. K. JENDER M.D.2, and J. L. WILSON M.D.2

1 Department of Bacteriology, University of Michigan Ann Arbor, Michigan
2 Department of Pediatrics and Communicable Diseases, University of Michigan Ann Arbor, Michigan

A single dose of 200-400,000 units of oral potassium penicillin V is absorbed rapidly in fasting febrile children and infants to produce high serum levels. These levels are similar to those of afebrile children in the same age groups. From this standpoint, therapy of acutely ill febrile children with oral potassium penicillin V in reliable when penicillin is indicated.