PEDIATRICS Vol. 32 No. 4 October 1963, pp. 509-516
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ECHO II VIRUS INFECTIONS ASSOCIATED WITH EXANTHEMS

James D. Cherry M.D.1, A. Martin Lerner M.D.1, Jerome O. Klein M.D.1, and Maxwell Finland M.D.1

1 Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services and Pediatric Service, Boston City Hospital, and the Department of Medicine, Harvard Medical School

Seven cases of ECHO 11 virus infection with exanthem are described. The etiologic relation of the rashes to the viruses is suggestive but not statistically validated. Evidence is presented that at least two antigenic variants were related to the cases reported and neither was closely related antigenically to the prototype strain. The data also suggested that HI test is more sensitive but less specific than the neutralization test in identifying infections with ECHO 11 viruses. A case with a chronic, recurrent vesicular rash was described in which an ECHO 11 virus was isolated from a lesion, but no corresponding antibody could be demonstrated in the patient's serum.

Accepted on March 26, 1963




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