PEDIATRICS Vol. 32 No. 4 October 1963, pp. 501-508
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Florman, A. L.
Right arrow Articles by Hodes, H. L.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Florman, A. L.
Right arrow Articles by Hodes, H. L.

RELATION OF 7S AND 19S STAPHYLOCOCCAL HEMAG-GLUTINATING ANTIBODY TO AGE OF INDIVIDUAL

Alfred L. Florman M.D.1, Gertrude H. Lambertson A.B.1, Helen Zepp A.B.1, Eugene Ainbender M.D.1, and Horace L. Hodes M.D.1

1 Stanley Jay Lagin Pediatric Research Laboratory, North Shore Hospital, Manhasset, and the Department of Pediatrics, The Mount Sinai Hospital, N.Y.C.

Staphylococcal hemagglutinating antibodies are present in both 7S and 19S fractions of serum. Newly born infants receive only 7S hemagglutinins from their mothers, and this passively acquired antibody soon disappears from the circulation. Infants under 4 months of age fail to respond to severe staphylococcal infections with hemagglutinin production. Infants over 4 months of age do make hemagglutinins, but these antibodies are mostly in the 19S class. Infants and children over 4 months of age may have high titers of hemagglutinins even without a history of staphylococcal infections. Most adults have significant staphylococcal hemagglutinin titers. The distribution of staphylococcal hemagglutinating antibodies between 7S and 195 is consistent. Under the age of 16 years, most of the actively acquired hemagglutinin is in the 19S class. After 16, 7S hemagglutinins may dominate. Thus, under the conditions of natural exposure to staphylococci, age of the individual is a significant determinant of the class of his staphylococcal hemaglutinating antibodies. Although it is clear from this and other reported studies that individuals react to different antigenic stimuli by making different classes of antibodies, the biological and clinical significance of these observations are not yet completely understood.

Accepted on March 29, 1963




This article has been cited by other articles:


Home page
 CLIN PEDIATRHome page
A. L. Florman
Basic Science Review : Nonspecific Resistance to Infection: Some Reflections and Personal Observations
Clinical Pediatrics, October 1, 1965; 4(10): 580 - 586.
[Abstract] [PDF]