PEDIATRICS Vol. 32 No. 3 September 1963, pp. 416-419
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TRANSFER OF BILIRUBIN-C14 ACROSS MONKEY PLACENTA

Roger Lester M.D.1, Richard E. Behrman M.D.2, and Jerold F. Lucey M.D.3

1 Thorndike Memorial Laboratory and Second and Fourth (Harvard) Medical Services, Boston City Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts
2 National Institute of Neurological Diseases and Blindness, Laboratory of Perinatal Physiology, San Juan, Puerto Rico
3 Department of Pediatrics, University of Vermont College of Medicine, Burlington, Vermont

Transfer of bilirubin across the placenta was studied in two pregnant Rhesus monkeys. Bilirubin-C14 was infused into a peripheral fetal vein and subsequently recovered from maternal bile. Significant transfer of bilirubin-C14 occurred in each experiment. It is probable that the placenta is a major site of fetal bilirubin transfer in primates.

Submitted on December 1, 1962
Accepted on April 29, 1963




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