PEDIATRICS Vol. 32 No. 2 August 1963, pp. 256
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SMITH, M. H. D.
Right arrow Search for Related Content
PubMed
Right arrow Articles by SMITH, M. H. D.

Resistance of Bacteria to the Penicillins. Ciba Foundation Study Group No. 13

MARGARET H. D. SMITH M.D.

This slender volume reports in lively form a 1962 Symposium concerned with the theoretical aspects of resistance of staphylococci to penicillin, and recent attempts to find new penicillins which would obviate this problem of resistance. Although it has been possible in the laboratory to render staphylococci penicillin-resistant without their producing penicillinase, nevertheless all naturally occurring penicillin-resistant strains of staphylococci are, without exception , penicillinase-producers. Small structural changes in the penicillin molecule might therefore be expected to alter markedly the affinity of the enzyme penicillinase for its substrate; recognition of this fact led several groups of organic chemists to systematically attempt to modify the benzyl penicillin (= penicillin G) molecule.