PEDIATRICS Vol. 32 No. 2 August 1963, pp. 239-250
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PEDIATRIC APPLICATION OF THE RADIOIODINE (1-131) ROSE BENGAL METHOD IN HEPATIC AND BILIARY SYSTEM DISEASE

William E. White M.D.1, John S. Welsh M.D.1, Daniel C. Darrow M.D.1, and Thomas M. Holder M.D.1

1 Departments of Radiology, Pediatrics, and Surgery of The Children's Mercy Hospital, Kansas City, Missouri

Rose bengal tagged with radioiodine (I-131) injected in the vein of a normal subject is rapidly cleared from the blood by the liver and conveyed by the biliary ducts to the intestine. By counting the radioactivity over the heart, liver, and intestine, the liver function (rate of clearing the blood of activity and rate of liver uptake) and patency of the biliary ducts (appearance of activity in the intestines) can be assessed. Patients with hepatitis clear the blood of dye slowly and exhibit a slow liver uptake. Intestinal activity appears somewhat slower than normal but in normal amount. In patients with biliary atresia, the blood is cleared of activity somewhat more slowly than normal. Liver activity, though rising slowly, continues to increase for a much longer period of time than in the normal subject. No activity reaches the intestine. Sixty-five nose bengal studies were carried out in 50 pediatric patients. The test is of most value in evaluating the jaundiced neonate. More experience with it will be necessary to evaluate fully the usefulness of this test.

Submitted on March 19, 1962
Accepted on March 1, 1963