PEDIATRICS Vol. 32 No. 2 August 1963, pp. 228-233
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INTESTINAL LACTASE DEFICIENCY IN A PATIENT WITH CYSTIC FIBROSIS

Report of a Case with Enzyme Assay

Frank J. Cozzetto M.D.1

1 Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado

The case of a 3 7/12-year-old boy with coexistent cystic fibrosis and intestinal lactase is reported. Disaccharide tolerance studies revealed normal serum glucose levels after oral ingestion of maltose, sucrose, and glucose-galactose, but abnormally low levels of serum glucose were obtained after lactose loading. Enzyme assay of a biopsy of the jejunal mucosa revealed normal sucrase, but markedly reduced lactase activity.

Submitted on December 11, 1962
Accepted on April 6, 1963