PEDIATRICS Vol. 32 No. 1 July 1963, pp. 4-9
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THE EFFECT OF MONTHLY GAMMA-GLOBULIN ADMINISTRATION ON MORBIDITY AND MORTALITY FROM INFECTION IN PREMATURE INFANTS DURING THE FIRST YEAR OF LIFE

Jules Amer M.D.1, Esther Ott R.N.1, Frank A. Ibbott F.I.M.L.T.1, Donough O'Brien M.D., M.R.C.P.1, and C. Henry Kempe M.D.1

1 Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado

A double-blind controlled study to determine the effect on infections of repeated administration of large doses of gamma-globulin to premature infants revealed that significantly more of these infants had no infections and fewer had mild infections during the first year of life. The data also suggests that gamma-globulin afforded some amelioration of serious but nonfatal infections. Deaths from infection showed a similar trend in favor of the gamma-globulin group, but this difference on its own was not significant.

Submitted on August 28, 1962
Accepted on March 22, 1963




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