PEDIATRICS Vol. 32 No. 1 July 1963, pp. 25-30
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CLOSURE OF THE DUCTUS ARTERIOSUS IN THE NEWBORN INFANT

Arthur J. Moss M.D.1, George Emmanouilides M.D.1, and Edward R. Duffie Jr. M.D.1

1 The Department of Pediatrics, School of Medicine, University of California, Los Angeles

Hemodynamic observations were made in 71 normal newborn infants up to 60 hours of age. A right-to-left or bidirectional shunt through the ductus arteriosus was demonstrated in 8 of 63 infants. Evidence of a definite left-to-right shunt was found in 7 of 30 infants. The data indicate that a bidirectional shunt is present shortly after birth and may persist for as long as 6 hours. This eventually becomes entirely left-to-right, and by 15 hours of age the shunting of blood either becomes physiologically insignificant or ceases entirely.

Submitted on October 31, 1962
Accepted on January 28, 1963




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