PEDIATRICS Vol. 31 No. 6 June 1963, pp. 996-1002
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ERYTHROKINETIC STUDIES OF THE ANEMIA OF LEAD POISONING

Sanford Leikin M.D.1 and Gloria Eng M.D.1

1 Children's Hospital of the District of Columbia, Washington, D.C.

Erythrokinetic studies using Fe59 and Cr51 simultaneously, and bone marrow myeloid-erythroid counts, were performed on seven children with the iron intractable anemia of lead poisoning. In all, a microcytic, hypochromic anemia was present. Normal results were obtained in one child. Three patients with relatively short histories of intoxication demonstrated a pattern consistent with a hemolytic process. The remaining three had more prolonged histories, and their erythrokinetic patterns displayed evidence of erythroid hypoplasia. These results indicate that lead involves hematopoesis by more than one mechanism and at several hematologic levels, depending upon the duration of toxicity.

Submitted on May 31, 1962
Accepted on January 8, 1963