PEDIATRICS Vol. 31 No. 6 June 1963, pp. 1041-1044
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The Treatment of Iron-deficiency Anemia—Palatable but Ineffective Iron Medication

LOUIS K DIAMOND M.D.1, J. LAWRENCE NAIMAN M.D.1, DONALD M. ALLEN M.D.1, and FRANK A. OSKI, M.D.1

1 The Department of Pediatrics, Harvard Medical School, and the Children's Hospital Medical Center, Boston, Massachusetts

Experience with a new oral iron-carbohydrate complex (Jefron) in the treatment of iron-deficiency anemia shows that the therapeutic results are inferior to those obtainable with ferrous sulfate. Many children showed no response after months of treatment with this drug and when subsequently placed on ferrous sulfate therapy showed a rapid rise in hemoglobin to normal levels. Preliminary studies suggest that poor gastrointestinal absorption may be a factor in the inadequate therapeutic effects.