PEDIATRICS Vol. 31 No. 5 May 1963, pp. 758-766
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CLINICAL IMPROVEMENT IN CHRONIC RENAL HYPERTENSION IN CHILDREN

Lawrence A. Caliguiri M.D.1, Alvin P. Shapiro M.D.1, and Malcolm A. Holliday M.D.1

1 Departments of Pediatrics and Medicine, University of Pittsburgh and Children's Hospital, Pittsburgh, Pennsylvania

Four children having diffuse renal disease and proteinuria were hospitalized because of hypertension developing after the onset of the kidney disease. The lability of the blood pressure particularly in response to anxiety in these children was far greater than is generally noted in adult patients with hypertensive renal disease. All of the patients had complete relief of symptoms due to their hyptertension, and in all four significant reduction in blood pressure was attained. The proteinuria associated with the kidney disease diminished in all four and disappeared in two patients. These results were associated with the use of hypotensive agents and with measures taken to relieve anxiety the patients had about their disease. The importance of the latter was suggested from the sensitivity in blood pressure response associated with anxietyproducing states.

Submitted on July 19, 1962
Accepted on September 12, 1962