PEDIATRICS Vol. 31 No. 4 April 1963, pp. 660-668
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THE EXCRETION OF DIHYDROXYPHENYLALANINE, DOPAMINE, AND DIHYDROXYPHENYLACETIC ACID IN NEUROBLASTOMA

T. L. Sourkes Ph.D.1, R. L. Denton M.D., C.M.1, G. F. Murphy M.Sc.1, Beatriz Chavez Q.F.1, and Simone Saint Cyr B.Sc.1

1 Allan Memorial Institute of Psychiatry, The Montreal Children's Hospital, and McGill University, Montreal, Quebec, Canada

Six cases of neuroblastoma and one of ganglioneuroma were studied with respect to excretion of dopamine and dopac (3,4-dihydroxyphenylacetic acid) in the urine. The quantities of these compounds were found to reflect the clinical status of the patient. In general, they were low during remission and increased just before and during relapse. In the urine of one patient, 3,4-dihydroxyphenylalanine was identified.

Submitted on July 11, 1962
Accepted on October 8, 1962