PEDIATRICS Vol. 31 No. 3 March 1963, pp. 463-469
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STAPHYLOCOCCAL ANTAGONISM TO PENICILLIN-G THERAPY OF HEMOLYTIC STREPTOCOCCAL PHARYNGEAL INFECTION

Effect of Oxacillin

Harold J. Simon M.D., Ph.D.1 and William Sakai B.A.1

1 The Division of Infectious Disease, Department of Medicine, Stanford University School of Medicine

Twelve pharyngeal specimens containing both group A hemolytic streptococci and coagulase-positive staphylococci were tested individually and together against penicillin-G and oxacillin. The hemolytic streptococci were always completely inhibited at very low concentrations of penicillin-G when tested individually. When combined with cultures of coagulase positive. penicillin-G destroying staphylococci, the inhibitory concentrations rose by a factor of 200. Similar tests with oxacillin showed no increase for inhibitory or bactericidal concentrations when the organisms were tested singly or in combination. Penicillin-G resistent staphylococci seemed to protect group A hemolytic streptococci from the action of penicillin-G. This was not the case when oxacillin was exhibited.

Submitted on June 5, 1962
Accepted on September 20, 1962




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