PEDIATRICS Vol. 31 No. 3 March 1963, pp. 444-454
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THE TRIAD OF THROMBOCYTOPENIA, ECZEMA, AND RECURRENT INFECTIONS (WISKOTT-ALDRICH SYNDROME) ASSOCIATED WITH MILK ANTIBODIES, GIANT-CELL PNEUMONIA, AND CYTOMEGALIC INCLUSION DISEASE

Allen W. Root M.D.1 and Carl E. Speicher M.C., U.S.A.F.1

1 The Departments of Pediatrics and Pathology of the Medical School of the University of Pennsylvania and the Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

A 3-year-old boy with the Wiskott-Aldrich syndrome has been described. In the course of study the child was found to have circulating antibodies to whole cow's milk; a peculiar cellular infiltrate in lymph nodes, spleen, and bone marrow; measles, giant-cell pneumonia, and cytomegalic inclusion disease. The patient improved on a milk-free diet, but no clear exacerbation of symptoms could be induced by milk ingestion. The combination of these clinical and pathological findings has not been reported previously in this syndrome.

Submitted on May 21, 1962
Accepted on July 13, 1962