PEDIATRICS Vol. 31 No. 3 March 1963, pp. 360-373
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CORTISOL PRODUCTION RATE IN NEWBORN BABIES, OLDER INFANTS, AND CHILDREN

Frederic M. Kenny M.D.1, Paul Malvaux M.D.1, and Claude J. Migeon M.D.1

1 Department of Pediatrics, Johns Hopkins University, School of Medicine

The rates of cortisol production by 22 newborn infants were estimated. Vaginally delivered full-term and premature infants had rates, which when corrected for surface area, were comparable to those for adults. Babies delivered by cesarean section, when studied under 38 hours of age, had low rates. Two babies with salt-losing congenital adrenal hyperplasia had the lowest values. In the newborns the urinary 17-OHCS were low, and represented a small, variable fraction of the cortisol production.

In a group of 14 older infants and children, the lowest production rates were observed in patients with adrenal calcification, moniliasis, hydrocephalus, and hypopituitarism. Administration of Wilhelmi growth hormone did not affect the production rates of the hypopituitary, or of the nonhypopituitary dwarfs.

Submitted on August 13, 1962
Accepted on November 5, 1962