PEDIATRICS Vol. 31 No. 2 February 1963, pp. 251-254
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METABOLIC ACIDOSIS IN CHILDREN WITH SEVERE CYANOTIC CONGENITAL HEART DISEASE

Norman L. Gootman M.D.1, Emile M. Scarpelli M.D.1, and Abraham M. Rudolph M.D.1

1 Department of Pediatrics, Albert Einstein College of Medicine, New York 61

Four children with severe cyanotic congenital heart disease and markedly reduced effective pulmonary blood flow were studied by cardiac catheterization. All children were severely hypoxic and acidotic, while the sytemic arterial pCO2 was relatively normal. These factors tended to maintain respiratory activity at a high level. However, due to the decreased pulmonary flow, respiratory compensation for the acidosis was ineffective. The chronic, uncompensated metabolic acidosis and hypoxemia suggested that (1) anaerobic tissue metabolism is significant, and (2) renal function may be compromised, in children with severe cyanotic congenital heart disease.

Submitted on April 9, 1962
Accepted on May 17, 1962




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G. M. Folger JR
Acidemia of Cardiogenic Origin in Young Infants with Cyanotic Congenital Heart Abnormalities: Pathogenesis, Diagnosis and Treatment, with Particular Emphasis on Neonatal Acid-base Disturbance
Clinical Pediatrics, October 1, 1972; 11(10): 573 - 579.
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