PEDIATRICS Vol. 31 No. 2 February 1963, pp. 222-225
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AN UNUSUAL EPIDEMIC OF METHEMOGLOBINEMIA

Robert R. Johnson M.D.1, Remo Navone A.B.1, and Ernest L. Larson B.S.1

1 Bureau of Occupational Health, Division of Preventive Medical Services, and Branch Public Health Laboratory, Division of Laboratories, California State Department of Public Health, Los Angeles

An outbreak of secondary methemoglobinemia was directly traceable to an aromatic amino compound present in the soap used for the preparation of enema solutions. This compound, while not itself a producer of methemoglobin, did, under the conditions of use, become converted into a substance which produced methemoglobin. Users of materials containing aromatic amino compounds should be aware of the possibility of such occurrences.

Submitted on May 21, 1962
Accepted on June 26, 1962