PEDIATRICS Vol. 31 No. 2 February 1963, pp. 209-221
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ANTIBODIES TO COW'S MILK PROTEINS—THEIR PRESENCE AND SIGNIFICANCE

Raymond D. A. Peterson M.D.1 and Robert A. Good Ph.D., M.D.1

1 Pediatric Research Laboratories of the Variety Club Heart Hospital, University of Minnesota

A study was made of antibodies to cow's milk proteins in the sera of 288 persons, mostly children. The sera were assayed for both precipitating and hemagglutinating antibody. Comparisons between the two systems are presented. The incidence of precipitins and/or elevated hemagglutinating titers was analyzed by age, nature of illness, and duration of disability. Chronically disabled children, as a group, had sigficantly higher titers than did normal or acutely ill children. Grouped patients with recurrent or chronic pneumonia, and Aldrich's and Hurler's syndromes, had higher titers than even the other chronically ill children. In the majority of cases it was not possible to attribute a pathogenetic role to the observed antibody. Whether or not these antibodies can be responsible for disease under special circumstances remains unknown.

Submitted on April 25, 1962
Accepted on July 19, 1962