PEDIATRICS Vol. 31 No. 1 January 1963, pp. 72-79
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CHROMOSOMAL ABERRATION IN AN INFANT FOLLOWING THE USE OF DIAGNOSTIC X-RAYS

P. E. Conen M.B., B.S., M.R.C.P.1, A. G. Bell M.D.1, and N. Aspin Ph.D.1

1 The Research Institute and Departments of Pathology, Genetics and Radiology of The Hospital for Sick Children, Toronto, and the University of Toronto

Chromosome studies were performed on an infant with congenital anomalies, since abnormal karyotypes have been found associated with certain patterns of anomalies. The only chromosome abnormalities found were structural changes, including some of the type seen following exposure to ionizing radiation. A detailed investigation was made of the roentgenographic studies made in this case. A dose of only 0.825 rads total body radiation may have caused the chromosome aberrations detected in the cultured leukocytes, although there are alternative explanations in this malformed child. Infants and small children are more likely to receive a higher dose of irradiation than adults during roentgenographic examinations because of the difficulty in maintaining correct position and shielding small areas.

Submitted on September 26, 1961
Accepted on August 16, 1962