PEDIATRICS Vol. 31 No. 1 January 1963, pp. 65-71
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A STUDY OF THE POSSIBLE RELATIONSHIP OF PROGESTERONE TO COLIC

Robert L. Clark A.B.1, Frank M. Ganis Ph.D.1, and William L. Bradford M.D.1

1 Departments of Pediatrics and Biochemistry, University of Rochester, School of Medicine and Dentistry, Rochester, New York

A series of 15 noncolic infants ranging in age from 6 days to 3 months was studied to determine pregnanediol glucuronide (PDG) excretion in urine. All these infants showed appreciable PDG spots by sensitive chromatographic techniques. In contrast, eight "colic" infants were studied, and it was found that these infants excreted none or only trace amounts of PDG in their urines. Seven other "colic" infants also showed no urinary PDG spots before hormone administration but demonstrated remission of symptoms and chromatographic spots after treatment. It is suggested that one cause of colic may involve progesterone deficiency and that in such instances the symptoms may be alleviated by the administration of a short course of oral progestational hormone.

Submitted on February 12, 1962
Accepted on June 29, 1962


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