PEDIATRICS Vol. 31 No. 1 January 1963, pp. 58-64
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HUMAN GROWTH HORMONE IN INFANT MALNUTRITION

Fernando Mönckeberg M.D.1, Gonzalo Donoso M.D.1, Sergio Oxman 1, Nelly Pak 1, and Julio Meneghello M.D.1

1 Universidad de Chile, Hospital Manuel Arrirán, Santiago, Chile Departamento de Nutrición, Universidad de Chile

Human growth hormone was used in the treatment of six malnourished infants who had previously failed to respond or gain weight, in spite of a diet adequate for their growth requirements. The hormone was administered, by intramuscular injection, in a dosage of 2 mg weekly for 4 consecutive weeks. During the administration of the hormone a significant gain in weight and proportionally increased nitrogen, phosphorus, and potassium retention was produced. After discontinuation of the hormone, the increased rate of weight gain and the increased positive balances for these elements was not sustained. Our findings suggest that a decrease in all hormones produced by the adenohypophysis in the child suffering from severe malnutrition may serve as an important adaptation mechanism which may increase his chances of survival.

Submitted on February 2, 1962
Accepted on July 26, 1962