PEDIATRICS Vol. 30 No. 5 November 1962, pp. 707-711
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LOWER INCIDENCE OF SEX CHROMATIN IN BUCCAL SMEARS OF NEWBORN FEMALES

David W. Smith M.D.1, Philip M. Marden B.A.1, Michael J. McDonald B.S.1, and Mark Speckhard M.D.1

1 Department of Pediatrics, University of Wisconsin Medical School, and St. Mary's Hospital, Madison, Wisconsin

The incidence of the sex chromatin mass in buccal cells of newborn females is often lower during the first day or two of postnatal life, as compared to later ages. This finding allows for misinterpretation of the significance of buccal smear results during the first day or two. A similar phenomenon was noted in mothers during the day prior to delivery and for one to two days thereafter. This suggests a common etiology for this effect in both the mother and the newborn infant.




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A. Robinson and T. T. Puck
Sex Chromatin in Newborns: Presumptive Evidence for External Factors in Human Nondisjunction
Science, April 2, 1965; 148(3666): 83 - 85.
[Abstract] [PDF]